Benign cancer of bone


It arises mostly in the second decade of life, affecting mainly the ends of the long tubular bones. The purpose of this study is to contrast two different forms of presentation of the same histologic entity: one case of a year-old male patient with a chondroblastoma lo­ca­ted in the proximal humerus, and the case of a year-old male patient with a chondroblastoma of the cal­ca­neus. The mor­phological fea­tures, benign cancer of bone aspects benign cancer of bone im­mu­no­his­tochemical stu­dies have been assessed.

None of the cases presented with spe­ci­fic radiologic signs for chondroblastoma, both lesions being osteolytic and well-delineated, in favor of a benign en­ti­ty. The classic mor­pho­lo­gical aspects of chondroblastoma re­pre­sen­ted by tumor cells with round wart virus dies shape and nuclei with longitudinal grooves were as­so­cia­ted with variable amounts of chondroid matrix, pe­ri­cellular calcification and few randomly distributed osteo­clast-like giant cells.

The im­mu­no­his­to­chemical studies showed the osteoblastic and chon­dro­blastic phenotype of the neoplastic cells, sustained benign cancer of bone positivity for CD56 and S All cases were treated by curettage with bone graf­ting, without recurrence in the short-term follow-up. Given the nonspecific radiologic findings and the histologic he­te­ro­ge­nei­ty, chondroblastoma is sometimes misinterpreted as a ma­lig­nant tumor, while this neoplastic lesion has a benign be­havior and benefits from conservative surgical treatment only.

Se întâlneşte frecvent în a doua decadă a vieţii şi este lo­ca­li­zat în majoritatea cazurilor la nivelul epifizelor oaselor lungi. Sco­pul acestui studiu este de a compara două forme di­fe­rite de prezentare ale aceleiaşi en­ti­tăţi histopatologice. Primul caz este reprezentat de benign cancer of bone pa­cient de gen masculin, în vârstă de 19 ani, cu condroblastom la nivelul epifizei hu­me­rale proximale, iar al doilea caz este al unui pacient de gen masculin, de 37 de ani, benign cancer of bone condroblastom lo­ca­lizat la nivelul calcaneului.

S-au evaluat aspectele ra­dio­­lo­gice şi histologice ale tumorii şi s-a analizat profilul imu­­no­histochimic al celulelor neoplazice. Investigaţiile ima­gis­ti­ce au evidenţiat leziuni osteolitice bine delimitate, fără ca­rac­te­re de specificitate, cu aspect radiologic benign. Ca­rac­te­ris­ticile histopatologice clasice ale condroblastomului sunt repre­zen­tate de celule rotunde, poligonale, cu nuclei in­dentaţi lon­gi­tu­dinal, reniformi, asociate benign cancer of bone o cantitate va­ria­bilă de matrice condroidă, calcificări pericelulare şi rare ce­lu­le gigante osteo­clast-like distribuite aleatoriu.

Testele imu­no­his­to­chi­mice au demonstrat fenotipul osteoblastic şi condroblastic al celu­le­lor tumorale, fiind pozitive pentru CD56 şi, respectiv, S Ambele cazuri au fost tra­ta­te prin chiuretaj şi plombaj cu grefă osoasă, prezentând o evo­lu­ţie favorabilă, fără re­ci­di­vă postoperatorie.

Ţinând cont de aspectele radiologice ne­spe­ci­fice şi de heterogenitatea tră­să­tu­rilor histopatologice, con­dro­blas­to­mul poate fi perceput une­ori ca o tumoră ma­lig­nă, deşi această entitate are un com­por­ta­ment benign şi se tra­tea­ză exclusiv chirurgical. It arises mostly in the second decade of life, being more prevalent in men, and affects mainly the ends of the long tubular bones of the skeletally immature individuals.

The common sites of involvement include the epiphysis of proximal humerus, proximal and distal femur and proximal tibia In older individuals, the location varies more and may include non-tubular bones, craniofacial bones, bones of hands and feet 7.

This entity has also been described in flat bones such as clavicle, sternum, ribs, vertebrae, pelvis and patella 5. It is usually a solitary lesion, which involves the medullary cavity of the long bones 3.

warts on hands how to remove

In flat bones, the tumor may extend into apophysis and into the articular space. Even though epiphysis of long tubular bones represents the common site of presentation, there are cases reported to arise in non-epiphyseal locations 8.

The most common clinical symptom is pain, which can be accompanied by other changes, such as swelling, stiffness, effusion and limitation in range of motion 6. On plain radiographs, chondroblastoma appears as a well-circumscribed, eccentric, radiolucent lesion with a thin sclerotic rim 9. The computed tomography can reveal areas of mineralization.

tratament pentru infecția cu viermi

Calcifications appear as radiodensities and their amount varies greatly. When present in the chondroid matrix, they are described as arcs and rings of calcification Adjacent cortex may be eroded or thinned, but rarely benign cancer of bone. In those cases associated with pathological fracture, a periosteal reac­tion may be seen. Lesions that do not arise in the epi­phy­sis have nonspecific imaging findings 3.

The differential diagnosis based on radiologic ima­ging includes giant cell tumor of bone, enchondroma, benign cancer of bone fibroma, low-grade chondrosarcoma, low-grade intramedullary osteosarcoma, and clear cell chon­dro­sar­coma The peritumoral inflammatory reaction especially edema may be assessed through MRI studies 9. The intensity of T1- and T2-weighted MRI images depends on the amounts of various components within the lesion, such as cartilaginous component, cellularity, calcification, hemorrhage and cystic areas 9.

Benign cancer of bone, Bone Tumor Imaging: Xiaoguang Cheng · | Books Express

Tissue is often obtained from curettage and comes in many fragments, giving the impression of a lobular ar­chi­tec­ture. It presents as benign cancer of bone grey yellow, friable ma­te­rial, usually with gritty cut surface calcifications.

The chondroid component appears as a rubbery blue gray material, sometimes with bone consistency. The frag­ments may be hemorrhagic 3. Histologically, this tumor is characterized by a pro­li­fe­ration of chondroblasts, chondroid plasturi detoxifiere pareri, cal­ci­fi­ca­tions, various amounts of giant cells, and is occasionally as­so­cia­ted with aneurysmal bone cyst ABC.

Tumoral cells have a round polygonal shape, with well-defined cyto­plas­mic borders. The cytoplasm may be eosinophilic or focally clear. The benign osteoclast-like giant cells of small di­men­sions are randomly dis­tri­bu­ted through the tumor, but their presence is not benign cancer of bone.

The presence of atypical mitoses excludes the diagnosis of chondroblastoma. Foci of hemosiderin deposition may be seen in the cytoplasm of the neoplastic cells.

Half of the tumors of the hand and feet develop secondary ABC. Some tumors may be locally aggressive, with cortical breakthrough and soft tissue invasion Tumor necrosis and new bone formation can be seen when pathologic fracture is associated An interesting relatively sensitive and specific marker for chondroblastoma is DOG1, which is known to be highly specific for gastrointestinal stromal tumors SOX9 is positive in both chondroblastoma and chondromyxoid fibroma.

Bone and cartilage tumors Prostatică obstrucție carcinom Benign cancer of bone Home Prostatică obstrucție carcinom This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. Prostate cancer is considered a benign cancer of bone tumor because it is a mass of cells that can invade other areas of the body. Glossary of Terms.

Immunohistochemistry using antibodies against H3K36M is already available in some centers Depending on benign cancer of bone histopathologic aspects, the dif­fe­ren­tial diagnosis may include giant cell tu­mor of bone, chon­dro­myxoid fibroma, secondary aneu­rys­mal bone cyst, clear cell chondrosarcoma, and chon­dro­blas­to­ma-like variant of osteosarcoma The treatment of choice is the complete surgical cu­ret­­tage with or without bone grafting.

As in giant cell tu­mor of bone GCTthe chemical cauterization with phe­nol and cryotherapy may be used during the sur­gi­cal pro­ce­dure. En bloc resection may be necessary if ag­gres­sive recurrences occur and they cannot be treated by curet­tage Amputation is an exceptional event.

cancer pancreatic treatment

Radiotherapy, previously used, is not yet recom­men­ded, as it leads to postradiation malignancy 3. It can be used when complete resection is not possible.

Benign cancer of bone, Benign cancer of bone - adakindergarten.ro

Che­mo­the­rapy is not indicated The patients were admitted for pain and movement limitation. Clinical and imagistic records, as well as treatment and postoperative evolution were gathered hepatofit 2 the hospital record system.

In our laboratory, we assessed histopathological diagnosis and im­mu­no­his­to­chemistry IHC studies. Solid tumors diameters were measured using computed tomography. The histologic sections were cut at 3 micrometers thickness. The standard stain was hematoxylin and eosin. DOG1 stain Biocare mouse monoclonal hpv autoimmune disease was performed manually. The histologic features evaluated included: giant cells, pattern of calcification, bone metaplasia, mitoses, chondroid material, cytologic atypia, necrosis, mature hyaline cartilage formation, and the presence of ABC.

Case 1 A year-old male patient was admitted in our hospital for short-term persistent pain two months localized in the left shoulder.

The imaging investigations revealed a well-de­li­neated expansile tumoral lesion in­vol­ving proximal left hu­meral epiphysis Figure 1. The bone lesion measured As imaging findings fa­vored a benign process, but associated with a rather broad dif­fe­ren­tial diagnosis, a bone biopsy was performed. The sheet-like proliferation of tumoral cells was associated with chon­droid matrix formation, bone me­ta­plasia benign cancer of bone focal cal­ci­fi­ca­tions of chondroid matrix Figure 2.

Benign cancer of bone

Only a small number of osteo­clast-like giant cells were pre­sent. Obvious cytologic atypia was absent. After the diagnosis of chondroblastoma was rendered, the surgical treatment was decided.

The patient under­went curettage and grafting with allograft bone.

Benign cancer of bone

The postoperative course was uneventful. Figure 1. Imaging findings of chon­dro­blas­toma in a year-old patient.

papiloma trece de la sine

Figure 2. Histologic aspects of chondroblastoma. Case 2 A year-old male patient was benign cancer of bone in our hospital for pain in the left foot. Conventional radiographs showed a well demarcated lytic lesion with a sclerotic rim, suspicious of a cystic benign lesion, situated in the subthalamic region of the calcaneus Figure 3. Frozen section diagnosis of chondroblastoma was rendered Figure 4B. The patient underwent de­fi­ni­tive surgery in one step, with curettage and bone graf­ting with allograft bone.

The microscopic features revealed sheets of polygonal cells with well-defined cell borders and nuclei with characteristic longitudinal grooves.

These aspects were associated with islands of calcified chondroid matrix. Rare osteoclast-like giant cells were randomly distributed. The mitotic activity was low, with no atypical figures.

Resection of a malignant bone tumour in the left proximal humerus

Hemorrhagic areas with hemosiderin deposition were also present Figure 4C. Figure 3. A Conventional radiograph of a chon­dro­blas­toma shows a well-de­mar­cated lytic le­sion with a sclerotic rim si­tua­ted in the subthalamic re­gion of the calcaneus; B Ra­dio­gra­phic findings after sur­gi­cal treatment Figure 4.

creșterea verucilor genitale

Chondroblastoma in a year-old patient. Figure 5.