Benign cancer of bone
It arises mostly in the second decade of life, affecting mainly the ends of the long tubular bones. The purpose of this study is to contrast two different forms of presentation of the same histologic entity: one case of a year-old male patient with a chondroblastoma located in the proximal humerus, and the case of a year-old male patient with a chondroblastoma of the calcaneus. The morphological features, benign cancer of bone aspects benign cancer of bone immunohistochemical studies have been assessed.
None of the cases presented with specific radiologic signs for chondroblastoma, both lesions being osteolytic and well-delineated, in favor of a benign entity. The classic morphological aspects of chondroblastoma represented by tumor cells with round wart virus dies shape and nuclei with longitudinal grooves were associated with variable amounts of chondroid matrix, pericellular calcification and few randomly distributed osteoclast-like giant cells.
The immunohistochemical studies showed the osteoblastic and chondroblastic phenotype of the neoplastic cells, sustained benign cancer of bone positivity for CD56 and S All cases were treated by curettage with bone grafting, without recurrence in the short-term follow-up. Given the nonspecific radiologic findings and the histologic heterogeneity, chondroblastoma is sometimes misinterpreted as a malignant tumor, while this neoplastic lesion has a benign behavior and benefits from conservative surgical treatment only.
Se întâlneşte frecvent în a doua decadă a vieţii şi este localizat în majoritatea cazurilor la nivelul epifizelor oaselor lungi. Scopul acestui studiu este de a compara două forme diferite de prezentare ale aceleiaşi entităţi histopatologice. Primul caz este reprezentat de benign cancer of bone pacient de gen masculin, în vârstă de 19 ani, cu condroblastom la nivelul epifizei humerale proximale, iar al doilea caz este al unui pacient de gen masculin, de 37 de ani, benign cancer of bone condroblastom localizat la nivelul calcaneului.
S-au evaluat aspectele radiologice şi histologice ale tumorii şi s-a analizat profilul imunohistochimic al celulelor neoplazice. Investigaţiile imagistice au evidenţiat leziuni osteolitice bine delimitate, fără caractere de specificitate, cu aspect radiologic benign. Caracteristicile histopatologice clasice ale condroblastomului sunt reprezentate de celule rotunde, poligonale, cu nuclei indentaţi longitudinal, reniformi, asociate benign cancer of bone o cantitate variabilă de matrice condroidă, calcificări pericelulare şi rare celule gigante osteoclast-like distribuite aleatoriu.
Testele imunohistochimice au demonstrat fenotipul osteoblastic şi condroblastic al celulelor tumorale, fiind pozitive pentru CD56 şi, respectiv, S Ambele cazuri au fost tratate prin chiuretaj şi plombaj cu grefă osoasă, prezentând o evoluţie favorabilă, fără recidivă postoperatorie.
Ţinând cont de aspectele radiologice nespecifice şi de heterogenitatea trăsăturilor histopatologice, condroblastomul poate fi perceput uneori ca o tumoră malignă, deşi această entitate are un comportament benign şi se tratează exclusiv chirurgical. It arises mostly in the second decade of life, being more prevalent in men, and affects mainly the ends of the long tubular bones of the skeletally immature individuals.
The common sites of involvement include the epiphysis of proximal humerus, proximal and distal femur and proximal tibia In older individuals, the location varies more and may include non-tubular bones, craniofacial bones, bones of hands and feet 7.
This entity has also been described in flat bones such as clavicle, sternum, ribs, vertebrae, pelvis and patella 5. It is usually a solitary lesion, which involves the medullary cavity of the long bones 3.
In flat bones, the tumor may extend into apophysis and into the articular space. Even though epiphysis of long tubular bones represents the common site of presentation, there are cases reported to arise in non-epiphyseal locations 8.
The most common clinical symptom is pain, which can be accompanied by other changes, such as swelling, stiffness, effusion and limitation in range of motion 6. On plain radiographs, chondroblastoma appears as a well-circumscribed, eccentric, radiolucent lesion with a thin sclerotic rim 9. The computed tomography can reveal areas of mineralization.
Calcifications appear as radiodensities and their amount varies greatly. When present in the chondroid matrix, they are described as arcs and rings of calcification Adjacent cortex may be eroded or thinned, but rarely benign cancer of bone. In those cases associated with pathological fracture, a periosteal reaction may be seen. Lesions that do not arise in the epiphysis have nonspecific imaging findings 3.
The differential diagnosis based on radiologic imaging includes giant cell tumor of bone, enchondroma, benign cancer of bone fibroma, low-grade chondrosarcoma, low-grade intramedullary osteosarcoma, and clear cell chondrosarcoma The peritumoral inflammatory reaction especially edema may be assessed through MRI studies 9. The intensity of T1- and T2-weighted MRI images depends on the amounts of various components within the lesion, such as cartilaginous component, cellularity, calcification, hemorrhage and cystic areas 9.
Benign cancer of bone, Bone Tumor Imaging: Xiaoguang Cheng · | Books Express
Tissue is often obtained from curettage and comes in many fragments, giving the impression of a lobular architecture. It presents as benign cancer of bone grey yellow, friable material, usually with gritty cut surface calcifications.
The chondroid component appears as a rubbery blue gray material, sometimes with bone consistency. The fragments may be hemorrhagic 3. Histologically, this tumor is characterized by a proliferation of chondroblasts, chondroid plasturi detoxifiere pareri, calcifications, various amounts of giant cells, and is occasionally associated with aneurysmal bone cyst ABC.
Tumoral cells have a round polygonal shape, with well-defined cytoplasmic borders. The cytoplasm may be eosinophilic or focally clear. The benign osteoclast-like giant cells of small dimensions are randomly distributed through the tumor, but their presence is not benign cancer of bone.
The presence of atypical mitoses excludes the diagnosis of chondroblastoma. Foci of hemosiderin deposition may be seen in the cytoplasm of the neoplastic cells.
Half of the tumors of the hand and feet develop secondary ABC. Some tumors may be locally aggressive, with cortical breakthrough and soft tissue invasion Tumor necrosis and new bone formation can be seen when pathologic fracture is associated An interesting relatively sensitive and specific marker for chondroblastoma is DOG1, which is known to be highly specific for gastrointestinal stromal tumors SOX9 is positive in both chondroblastoma and chondromyxoid fibroma.
Bone and cartilage tumors Prostatică obstrucție carcinom Benign cancer of bone Home Prostatică obstrucție carcinom This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. Prostate cancer is considered a benign cancer of bone tumor because it is a mass of cells that can invade other areas of the body. Glossary of Terms.
Immunohistochemistry using antibodies against H3K36M is already available in some centers Depending on benign cancer of bone histopathologic aspects, the differential diagnosis may include giant cell tumor of bone, chondromyxoid fibroma, secondary aneurysmal bone cyst, clear cell chondrosarcoma, and chondroblastoma-like variant of osteosarcoma The treatment of choice is the complete surgical curettage with or without bone grafting.
As in giant cell tumor of bone GCTthe chemical cauterization with phenol and cryotherapy may be used during the surgical procedure. En bloc resection may be necessary if aggressive recurrences occur and they cannot be treated by curettage Amputation is an exceptional event.
Radiotherapy, previously used, is not yet recommended, as it leads to postradiation malignancy 3. It can be used when complete resection is not possible.
Benign cancer of bone, Benign cancer of bone - adakindergarten.ro
Chemotherapy is not indicated The patients were admitted for pain and movement limitation. Clinical and imagistic records, as well as treatment and postoperative evolution were gathered hepatofit 2 the hospital record system.
In our laboratory, we assessed histopathological diagnosis and immunohistochemistry IHC studies. Solid tumors diameters were measured using computed tomography. The histologic sections were cut at 3 micrometers thickness. The standard stain was hematoxylin and eosin. DOG1 stain Biocare mouse monoclonal hpv autoimmune disease was performed manually. The histologic features evaluated included: giant cells, pattern of calcification, bone metaplasia, mitoses, chondroid material, cytologic atypia, necrosis, mature hyaline cartilage formation, and the presence of ABC.
Case 1 A year-old male patient was admitted in our hospital for short-term persistent pain two months localized in the left shoulder.
The imaging investigations revealed a well-delineated expansile tumoral lesion involving proximal left humeral epiphysis Figure 1. The bone lesion measured As imaging findings favored a benign process, but associated with a rather broad differential diagnosis, a bone biopsy was performed. The sheet-like proliferation of tumoral cells was associated with chondroid matrix formation, bone metaplasia benign cancer of bone focal calcifications of chondroid matrix Figure 2.
Benign cancer of bone
Only a small number of osteoclast-like giant cells were present. Obvious cytologic atypia was absent. After the diagnosis of chondroblastoma was rendered, the surgical treatment was decided.
The patient underwent curettage and grafting with allograft bone.
Benign cancer of bone
The postoperative course was uneventful. Figure 1. Imaging findings of chondroblastoma in a year-old patient.
Figure 2. Histologic aspects of chondroblastoma. Case 2 A year-old male patient was benign cancer of bone in our hospital for pain in the left foot. Conventional radiographs showed a well demarcated lytic lesion with a sclerotic rim, suspicious of a cystic benign lesion, situated in the subthalamic region of the calcaneus Figure 3. Frozen section diagnosis of chondroblastoma was rendered Figure 4B. The patient underwent definitive surgery in one step, with curettage and bone grafting with allograft bone.
The microscopic features revealed sheets of polygonal cells with well-defined cell borders and nuclei with characteristic longitudinal grooves.
These aspects were associated with islands of calcified chondroid matrix. Rare osteoclast-like giant cells were randomly distributed. The mitotic activity was low, with no atypical figures.
Resection of a malignant bone tumour in the left proximal humerus
Hemorrhagic areas with hemosiderin deposition were also present Figure 4C. Figure 3. A Conventional radiograph of a chondroblastoma shows a well-demarcated lytic lesion with a sclerotic rim situated in the subthalamic region of the calcaneus; B Radiographic findings after surgical treatment Figure 4.
Chondroblastoma in a year-old patient. Figure 5.
