Search Menu Sir, The mumps, measles, and rubella MMR vaccination has been the subject of controversy in recent years, particularly with respect to the proposed associations with autism and Crohn's disease [ 1 ]. Recent reports, however, have found no evidence to support such associations [ 2 ].
Despite this, chronic kidney disease guidelines result of the report by Wakefield et al. Renal biopsy revealed virtually complete obliteration of the arcuate artery by smooth muscle proliferation and mucoid change, with negative immunofluorescence studies.
Blood film examination showed fragmented red blood cells. On day 14, he developed acute renal failure, anaemia, and thrombocytopenia.
Renal biopsy revealed thrombotic microangiopathy, with negative immune studies. On subsequent exposure to the measles component of the MMR vaccine, the patient again developed an abnormal reaction, manifesting clinically as HUS.
HUS is also known to occur after other vaccinations. Filler et al. This child had previously had Henoch—Schönlein purpura at the age of 6 years. Renal disease has been reported following MMR vaccination.
Ahuja and Wright in [ 5 ] reported the case of a young child who developed nephrotic syndrome 6 days after receiving the MMR vaccine. It also serves to remind physicians of the importance of taking a thorough infection and vaccination history.