HCC pathophysiology, treatments and mechanisms
PMID: Abstract The drugs hepatotoxicity represents a major problem of the iatrogenic pathology, with various manifestations, directly through the hepatotoxic effect or through idiosycrasy reactions.
The hepatic affection induced by chemotherapy appears in children in cases of prolonged therapy, chronic diseases, or other associated conditions. Hepatotoxicity clinically develops through hepatic disorder, cholestatic or mixed hepato-cholestatic manifestations and systematic affection.
There are no specific hepatic cancer etiology or biochemical characteristics for diagnostic of hepatotoxicity.
The international criteria for asessing the hepatotoxicity includes the bilirubin, the transaminasis, GGT, FA, albumin and the flow on hepatic cancer etiology vein. It has been noticed that these parameters are not enough for the right assesssment of the chemotherapics' hepatotoxicity.
Hepatic cancer etiology Miron, M. HCC incidence has doubled over the last 20 years in Europe. The management of HCC patients depends mainly on the extent and location of the tumor and hepatic cancer etiology underlying liver disease. Three curative methods are currently available: orthotopic hepatic cancer etiology transplantation, surgical resection and local destruction.
Thus it is required the abdominal ultrasonography and computerised tomography for the identification of billiary tract, vascularisation, associated conditions and the degree of fibrosis; also, the hepatic biopsy may be necessary. Acustic radiation force imaging ARFI is an elastographic method which allows valid, accurate and flexible evaluation of liver stiffness, a quantification with a strong correlation with the fibrosis stage, not influenced by steatosis.
In conclusion, the hepatic toxicity showed by alterated hepatic biochemical tests and by symptomes of hepatopathy needs a proper appreciation of the hepatic modifications, which can be obtained through hepatic biopsy or by assessing the hepatic elasticity through elastography. Thus, real-time elastography is an useful tool in assessing the chemotherapics hepatotoxicity in children with cancer.